CRK Antibody

Catalog Number:

36372

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P46108
NCBI Gene ID: 1398
Gene Accssion: BC009837

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human v-crk avian sarcoma virus CT10 oncogene homolog

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CRK protein.

Applications:

IHC

Background:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF