FBXW7 Antibody

Catalog Number:

36334

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q969H0
NCBI Gene ID: 55294
Gene Accssion: BC117244

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FBXW7 protein.

Applications:

IHC

Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats.

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF