AANAT Antibody

Catalog Number:

36248

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q16613
NCBI Gene ID: 15
Gene Accssion: BC069434

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human aralkylamine N-acetyltransferase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total AANAT protein.

Applications:

IHC

Background:

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF