ASCC1 Antibody

Catalog Number:

36243

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8N9N2
NCBI Gene ID: 51008
Gene Accssion: BC012291

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human activating signal cointegrator 1 complex subunit 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ASCC1 protein.

Applications:

IHC

Background:

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF