EPS15L1 Antibody

Catalog Number:

36170

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UBC2
NCBI Gene ID: 58513
Gene Accssion: BC131590

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human epidermal growth factor receptor pathway substrate 15-like 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EPS15L1 protein.

Applications:

WB IHC

Background:

Epidermal growth factor receptor substrate 15-like 1?is a?protein?that in humans is encoded by the?EPS15L1gene. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) By similarity. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF