ASL Antibody

Catalog Number:

36128

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P04424
NCBI Gene ID: 435
Gene Accssion: BC008195

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human argininosuccinate lyase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ASL protein.

Applications:

IHC

Background:

This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF