GADD45B Antibody

Catalog Number:

36492

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75293
NCBI Gene ID: 4616
Gene Accssion: BC113466

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GADD45B protein.

Applications:

IHC

Background:

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF