ALAS1 Antibody

Catalog Number:

36073

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P13196
NCBI Gene ID: 211
Gene Accssion: BC011798

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human aminolevulinate, delta-, synthase 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ALAS1 protein.

Applications:

IHC

Background:

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF