AADACL2 Antibody

Catalog Number:

36002

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q6P093
NCBI Gene ID: 344752
Gene Accssion: BC065724

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human arylacetamide deacetylase-like 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total AADACL2 protein.

Applications:

IHC

Background:

AADAC is a 45 kDa membrane-associated hydrolase highly expressed in the human liver that has been implicated in the hydrolysis of arylacetamide xenobiotics including flutamide and phenacetin.556¨C560AADAC is highly homologous to several related lipases, AADACL1, 2, and 4, the latter two of which remain completely unannotated. Overexpression of AADAC in a rat hepatoma cell line produces changes in cellular TG levels, apoplipoprotein B secretion, and fatty acid oxidation, but the mechanism for these effects remains unclear.561?Candidate endogenous substrates, selective inhibitors, or knockout mice have not, to our knowledge, been described for AADAC or the related enzymes AADACL2 and AADACL4.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF