MAP3K12 Antibody

Catalog Number:

35948

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q12852
NCBI Gene ID: 7786
Gene Accssion: BC050050

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human mitogen-activated protein kinase kinase kinase 12

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAP3K12 protein.

Applications:

IHC

Background:

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF