SOCS2 Antibody

Catalog Number:

35922

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14508
NCBI Gene ID: 8835
Gene Accssion: BC010399

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human suppressor of cytokine signaling 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SOCS2 protein.

Applications:

IHC

Background:

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF