ROCK1 Antibody

Catalog Number:

35907

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13464
NCBI Gene ID: 6093
Gene Accssion: BC113114

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human Rho-associated, coiled-coil containing protein kinase 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ROCK1 protein.

Applications:

IHC

Background:

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF