PDCD4 Antibody

Catalog Number:

35873

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q53EL6
NCBI Gene ID: 27250
Gene Accssion: BC026104

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human programmed cell death 4 (neoplastic transformation inhibitor)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PDCD4 protein.

Applications:

WB

Background:

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF