PAK7 Antibody

Catalog Number:

35866

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9P286
NCBI Gene ID: 57144
Gene Accssion: BC024179

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human p21 protein (Cdc42/Rac)-activated kinase 7

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PAK7 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:15-1:50

Datasheet PDF