PAK6 Antibody

Catalog Number:

35865

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NQU5
NCBI Gene ID: 56924
Gene Accssion: BC035596

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human p21 protein (Cdc42/Rac)-activated kinase 6

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PAK6 protein.

Applications:

IHC

Background:

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF