CDKN2AIP Antibody

Catalog Number:

35855

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NXV6
NCBI Gene ID: 55602
Gene Accssion: BC022270

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human CDKN2A interacting protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDKN2AIP protein.

Applications:

IHC

Background:

CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF