RB1 Antibody

Catalog Number:

35851

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P06400
NCBI Gene ID: 5925
Gene Accssion: BC039060

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human retinoblastoma 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RB1 protein.

Applications:

WB

Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF