MSH4 Antibody

Catalog Number:

35821

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O15457
NCBI Gene ID: 4438
Gene Accssion: BC033030

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human mutS homolog 4

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MSH4 protein.

Applications:

IHC

Background:

This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF