MMP12 Antibody

Catalog Number:

35817

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P39900
NCBI Gene ID: 4321
Gene Accssion: BC112301

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human matrix metallopeptidase 12 (macrophage elastase)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MMP12 protein.

Applications:

IHC

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF