CTDSP1 Antibody

Catalog Number:

34552

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9GZU7
NCBI Gene ID: 58190

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human CTDSP1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CTDSP1 protein.

Applications:

WB IHC

Background:

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Marquet S., Mamm. Genome 11:755-762(2000).
Yeo M., J. Biol. Chem. 278:26078-26085(2003).
Hillier L.W., Nature 434:724-731(2005)

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF