CHP2 Antibody

Catalog Number:

34512

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O43745
NCBI Gene ID: 63928

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of humanCHP2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CHP2 protein.

Applications:

WB

Background:

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Loftus B.J., Genomics 60:295-308(1999).
Wang Y., J. Immunol. 169:1102-1109(2002).
Pang T., J. Biol. Chem. 277:43771-43777(2002).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF