CASP10 Antibody

Catalog Number:

31137

Amount:

100μg

Price:

$319

Swiss-Prot No:

Genbank No.: NP_116759

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 485-499 amino acids of Human Caspase-10

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CASP10 protein.

Applications:

ELISA WB

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

References:

appl_detail:

Predicted MW: 59kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF