HLA-DMA Polyclonal Antibody

Catalog Number:

30759

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P28067
NCBI Gene ID:3108

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human HLA-DMA (NP_006111.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF