Product Datasheet  
TMEM59L Antibody  
Catalog Number: 25337  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9UK28
    Gene ID:25789
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 19 amino acid peptide near carboxy terminus of human TMEM59L.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Transmembrane protein 59L, brain-specific membrane-anchored protein, BSMAP
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
  • Applications：  
  • ELISA WB
  • Background：  
  • Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.



 
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