Product Datasheet  
JMJD1B Antibody  
Catalog Number: 24956  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q7LBC6
    Gene ID:51780
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 20 amino acid peptide from near the center of human JMJD1B.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • 5qNCA, Lysine-specific demethylase 3B, KDM3B
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody will not cross-react with JMJD1A or JMJD1C.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist.



 
© Signalway Biotechnology All Rights Reserved.