Product Datasheet  
IRGC Antibody  
Catalog Number: 24945  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q6NXR0
    Gene ID:56269
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 12 amino acid peptide near the carboxy terminus of human IRGC.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, Iigp5, CINEMA
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.
  • Applications：  
  • ELISA WB ICC
  • Background：  
  • Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.



 
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