Product Datasheet
AP3M1 Antibody
Catalog Number: 25324
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:Q9Y2T2
Gene ID:26985
- Form of Antibody:
- Supplied in PBS containing 0.02% sodium azide.
- Storage:
- Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Immunogen:
- Raised against a 15 amino acid peptide near the carboxy terminus of human AP3M1.
- other_names:
- Adaptor-related protein complex 3 mu-1 subunit, AP-3 complex subunit mu-1, mu3A
- Purification:
- Affinity chromatography purified via peptide column
- Specificity:
- AP3M1 antibody may cross-react with AP3M2.
- Background:
- The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3M1 is highly homologous to AP3M2 but is the preferred binding partner to the YQRL motif from the cytosolic domain of TGN38. AP3M1 has also been shown to interact with the HIV-1 virulence protein Nef.
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