Product Datasheet  
PCK1 Antibody  
Catalog Number: 49766  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P35558
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC: 1:50-1:200
    ICC: 1:50-1:200

  • other_names：  
  • cytosolic [GTP] antibody
    GTP antibody
    PCK1 antibody
    PCKGC_HUMAN antibody
    PEP carboxykinase antibody
    PEPCK-C antibody
    PEPCK1 antibody
    PEPCKC antibody
    Phosphoenolpyruvate carboxykinase 1 (soluble)
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • ICC,IHC,WB
  • Background：  
  • Normal adjustment to changes in blood glucose levels depends on insulin signaling as well as enzymes involved in the regulation of gluconeogenesis. Pathological changes to this process are central to the type 2 diabetes phenotype. Phosphoenolpyruvate carboxykinase (PEPCK) plays an important role in this process by stimulating hepatic glucose production. PEPCK expression increases in response to glucagon and glucocorticoids, while insulin suppresses expression. Modulation of the signals governing PEPCK levels present a potential therapeutic approach to the treatment of insulin resistance and consequently obesity. The cytosolic form of PEPCK, known as PEPCK-C, and the mitochondrial form, known as PEPCK-M, are encoded by two different nuclear genes in mouse, human and chicken.



 
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