Product Datasheet
gamma Sarcoglycan Antibody
Catalog Number: 49536
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q13326
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:500-1:2,000
IHC: 1:50-1:200
IP: 1:50-1:100
- other_names:
- 35 kDa dystrophin associated glycoprotein antibody
35 kDa dystrophin-associated glycoprotein antibody
35DAG antibody
35kD dystrophin associated glycoprotein antibody
35kDa dystrophin-associated glycoprotein antibody
A4 a
- Purification:
- ProA affinity purified
- Applications:
- WB, IP, IHC
- Background:
- The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
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