Product Datasheet
Gli1 Antibody
Catalog Number: 49399
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P08151
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:500-1:1,000
IHC:1:50-1:200
ICC: 1:50-1:200
- other_names:
- Gli 1 antibody
GLI antibody
GLI family zinc finger 1 antibody
GLI Kruppel family member 1 antibody
gli1 antibody
GLI1_HUMAN antibody
Glioma associated oncogene 1 antibody
Glioma associated oncogene homolog
- Purification:
- ProA affinity purified
- Applications:
- WB, ICC, IHC
- Background:
- Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-1 (GLI family zinc finger 1), also known as Glioma-associated oncogene or oncogene GLI, is a 1,106 amino acid protein that localizes to both the cytoplasm and nucleus, and belongs to the GLI C2H2-type zinc-finger protein family. GLI-1 acts as a transcriptional activator and is thought to play a role in craniofacial development. GLI-1 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 12q13.3.
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