Product Datasheet  
HMGCR Antibody  
Catalog Number: 49355  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P04035
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000-1:2,000



  • other_names：  
  • 3 hydroxy 3 methylglutaryl CoA reductase antibody
    3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody
    3 hydroxymethylglutaryl CoA reductase antibody
    3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody
    3-hydroxy-3-methylgluta
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP
  • Background：  
  • The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.



 
© Signalway Biotechnology All Rights Reserved.