Product Datasheet  
PDIA6 Antibody  
Catalog Number: 49340  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q15084
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000-1:2,000

    ICC: 1:100-1:500

    FC: 1:50-1:100
  • other_names：  
  • Endoplasmic reticulum protein 5 antibody
    ER protein 5 antibody
    ERp5 antibody
    P5 antibody
    Pdia6 antibody
    PDIA6_HUMAN antibody
    Protein disulfide isomerase A6 antibody
    Protein disulfide isomerase associated 6 antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC/IF, FC
  • Background：  
  • Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp5, also known as PDIA6 (protein disulfide isomerase family A, member 6) or TXNDC7 is a 440 amino acid protein that contains two thioredoxin domains and belongs to the protein disulfide isomerase family. Localized to the melanosome, as well as to the lumen of the endoplasmic reticulum, ERp5 functions to catalyze the rearrangement of disulfide bonds in a variety of different proteins. Via its catalytic activity, ERp5 is able to reduce the disulfide bond that binds MICA to tumor cells, thereby releasing MICA and reducing the rate of tumor expansion. Multiple isoforms of ERp5 exist due to alternative splicing events.



 
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