Product Datasheet
67kDa Laminin Receptor Antibody
Catalog Number: 49319
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P08865
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:100-1:500
FC: 1:50-1:100
- other_names:
- 34/67 kDa laminin receptor antibody 37 kDa laminin receptor precursor antibody 37/67 kDa laminin receptor antibody 37LRP antibody 40S ribosomal protein SA antibody 67 kDa laminin receptor antibody 67LR antibody Colon car
- Purification:
- ProA affinity purified
- Applications:
- WB, ICC/IF, IHC, IP, FC
- Background:
- Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma laminin-binding protein) and is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Additionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.
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