Product Datasheet  
Doublecortin Antibody  
Catalog Number: 49313  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O43602
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000-5,000



    FC: 1:50-1:100
  • other_names：  
  • DBCN antibody
    Dbct antibody
    DC antibody
    DCX antibody
    DCX_HUMAN antibody
    Doublecortex antibody
    Doublin antibody
    FLJ51296 antibody
    Lis X antibody
    Lis-X antibody
    Lissencephalin X antibody
    Lissencephalin-
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, resulting in severe mental retardation. Genetic analysis identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 shows sequence homology to β-subunits of heterotrimeric G proteins. Doublecortin contains a consensus Abl phosphorylation site, and it has some sequence homology to a predicted kinase protein. Both proteins are highly expressed in developing brain, suggesting that they may be involved in a signal transduction pathway that is crucial to brain development.



 
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