Product Datasheet
Histone H1.0 Antibody
Catalog Number: 49133
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P07305
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200
- other_names:
- H1 histone family member 0 antibody H1(0) antibody H10 antibody H10_HUMAN antibody h1f0 antibody H1FV antibody Histone H1'' antibody Histone H1(0) antibody Histone H1.0 antibody Histone H10 antibody Histon
- Purification:
- ProA affinity purified
- Applications:
- WB, ICC/IF, IHC
- Background:
- Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
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