Product Datasheet  
SIRT2 Antibody  
Catalog Number: 49088  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q8IXJ6
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  


  • ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • FLJ35621 antibody
    FLJ37491 antibody
    NAD dependent deacetylase sirtuin 2 antibody
    NAD-dependent deacetylase sirtuin-2 antibody
    NAD-dependent protein deacetylase sirtuin-2 antibody
    Regulatory protein SIR2 homolog 2 antibod
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • ICC/IF, IP, FC
  • Background：  
  • The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.



 
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