Product Datasheet  
APC Antibody  
Catalog Number: 48998  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P25054
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Rt
  • appl_detail：  
  • WB: 1:1,000-5,000

    ICC: 1:50-1:200

  • other_names：  
  • Adenomatous Polyposis Coli antibody
    Adenomatous polyposis coli protein antibody
    Apc antibody
    APC_HUMAN antibody
    CC1 antibody
    Deleted in polyposis 2.5 antibody
    DP2 antibody
    DP2.5 antibody
    DP3 antibody
    FAP antibo
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IP
  • Background：  
  • The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardners syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. β-catenin and γ-catenin (also called plakoglobin), are involved in the regulation of cellular adhesion. APC and E-cadherin compete for binding to specific internal regions of both β- and γ-catenin. Interactions between cytoskeleton and the APC, E-cadherin, β/γ catenin complex are mediated by α-catenin.



 
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