Product Datasheet
Sonic Hedgehog Protein/SHH(C-Product) Antibody
Catalog Number: 48975
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q15465
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:1,000-1:2,000
IHC: 1:200-1:500
ICC: 1:50-1:200
FC: 1:50-1:100
- other_names:
- HHG 1 antibody HHG-1 antibody HHG1 antibody HLP 3 antibody HLP3 antibody Holoprosencephaly 3 antibody HPE 3 antibody HPE3 antibody MCOPCB5 antibody shh antibody SHH_HUMAN antibody SMMC I antibody
- Purification:
- ProA affinity purified
- Applications:
- WB, ICC/IF, IHC, FC
- Background:
- The Drosophila segment polarity gene hedgehog (hh) encodes a precursor protein which undergoes autocleavage to generate amino- and carboxy-terminal peptides. Both proteins are secreted and appear to function in embryonic and imaginal disc patterning. Several vertebrate homologs of Drosophila hh have been identified. These include Sonic hedgehog (Shh) (alternatively designated Vhh-1), Desert hedgehog (Dhh) and Indian hedgehog (Ihh). Each contain amino-terminal signal peptides and apparently function as secreted proteins involved in the mediation of various cell-cell interactions. Shh resembles Drosophila hh in that it is processed to generate an amino-terminal secreted peptide that is retained at or near the cell surface and a carboxy-terminal glycosylated more diffusible peptide.
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