Product Datasheet
COX2/Cyclooxygenase 2 Antibody
Catalog Number: 48935
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P35354
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:1,000-5,000
ICC: 1:50-1:200
- other_names:
- COX 2 antibody COX-2 antibody COX2 antibody Cyclooxygenase 2 antibody Cyclooxygenase 2b antibody Cyclooxygenase antibody Cyclooxygenase-2 antibody Cyclooxygenase2 antibody EC 1.14.99.1 antibody fj02a10 antibody
- Purification:
- ProA affinity purified
- Background:
- Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.
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