Product Datasheet
MCSF Antibody
Catalog Number: 48850
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P09603
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- recombinant protein
- appl_detail:
- WB: 1:500-1:1000
IHC: 1:50-1:100
ICC: 1:50-1:200
- other_names:
- Colony stimulating factor 1 (macrophage) antibody Colony stimulating factor 1 antibody Colony stimulating factor macrophage specific antibody CSF 1 antibody CSF-1 antibody CSF1 antibody CSF1_HUMAN antibody Csfm antibody<
- Purification:
- ProA affinity purified
- Applications:
- WB, IHC, ICC, IP
- Background:
- The macrophage colony-stimulating factor (M-CSF), also designated CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that can stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor cells. M-CSF is a homodimeric cytokine that is produced by fibroblasts, epithelial cells, bone marrow stromal cells, osteoblasts, keratinocytes, macrophages, T cells and B cells. M-CSF is a glycoprotein required for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF has also been identified as an important mediator of the inflammatory response and can regulate the release of proinflammatory cytokines from macrophages. M-CSF exerts its pleiotropic effects by binding to a single type of high affinity cell surface receptor that is encoded by the c-Fms proto-oncogene.
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