Product Datasheet  
p27 KIP 1 Antibody  
Catalog Number: 48842  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P46527
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu, Rt
  • appl_detail：  
  • WB: 1:1,000
    IHC: 1:100-1:500
    ICC: 1:100-1:500

    FC: 1:50-1:100
  • other_names：  
  • AA408329 antibody
    AI843786 antibody
    Cdki1b antibody
    CDKN 1B antibody
    CDKN 4 antibody
    CDKN1B antibody
    CDKN4 antibody
    CDN1B_HUMAN antibody
    Cyclin Dependent Kinase Inhibitor 1B antibody
    Cyclin dependent kinase inh
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC/IF, IHC, IP, FC
  • Background：  
  • Cell cycle progression is regulated by a series of cyclin-dependent kinases consisting of catalytic subunits, designated Cdks, as well as activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has recently been described that function as "mitotic inhibitors." These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16; and a more recently described p16-related inhibitor designated p15. A p21-related protein, p27, has been described as a negative regulator of G1 progression and speculated to function as a possible mediator of TGFβ-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and, to a lesser extent, with cyclin E and Cdk2.



 
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