Product Datasheet
Bcl-2 Antibody
Catalog Number: 48675
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.：
- Swiss-Prot#:P10415
- Form of Antibody：
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen：
- recombinant protein
- appl_detail：
- WB: 1:1,000-1:2,000
IHC: 1:50-1:500
ICC: 1:50-1:200
FC: 1:50-1:100
- other_names：
- Apoptosis regulator Bcl 2 antibody Apoptosis regulator Bcl-2 antibody Apoptosis regulator Bcl2 antibody AW986256 antibody B cell CLL/lymphoma 2 antibody B cell leukemia/lymphoma 2 antibody Bcl-2 antibody Bcl2 antibody
- Purification：
- ProA affinity purified
- Applications：
- WB, ICC/IF, IHC, IP, FC
- Background：
- Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xl, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.
![]()
© Signalway Biotechnology All Rights Reserved.