Product Datasheet  
MGMT Antibody  
Catalog Number: 48576  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P16455
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:500-1:1000
    IHC: 1:200
    ICC: 1:200

    FC:1:100
  • other_names：  
  • 6 O methylguanine DNA methyltransferase antibody
    6-O-methylguanine-DNA methyltransferase antibody
    Agat antibody
    AGT antibody
    AI267024 antibody
    EC 2.1.1.63 antibody
    Methylated DNA protein cysteine methyltransferase antibody
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O (6) position of guanine, restoring guanine to its normal form without causing DNA breaks. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It is ubiquitously expressed in normal human tissues and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy.



 
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