Product Datasheet
Dynamin 1 Antibody
Catalog Number: 48539
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q05193
- Form of Antibody:
- 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- Recombinant protein within human Dynamin 1 aa 575-750.
- appl_detail:
- WB: 1:500-1:1,000
IHC: 1:50-1:200
- other_names:
- B dynamin antibody
D100 antibody
DNM 1 antibody
DNM antibody
DNM1 antibody
DYN1_HUMAN antibody
Dynamin antibody
Dynamin-1 antibody
Dynamin1 antibody
- Purification:
- Protein affinity purified
- Background:
- Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity). The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.
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