Product Datasheet  
T-bet Antibody  
Catalog Number: 48536  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9JKD8
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide within human T-bet aa 480-530.
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:500



    FC: 1:50-1:100
  • other_names：  
  • T bet antibody
    T box 21 antibody
    T box expressed in T cells antibody
    T box protein 21 antibody
    T box transcription factor TBX21 antibody
    T cell specific T box transcription factor antibody
    T cell specific T box
  • Purification：  
  • Peptide affinity purified.
  • Specificity：  
  • Applications：  
  • WB,FC
  • Background：  
  • T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T box expressed in T cells) is a Th1-specific T box transcription factor that controls the expres-sion of the Th1 cytokine, IFN-γ. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. T-bet is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.



 
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