Product Datasheet  
HIF1 alpha Antibody  
Catalog Number: 48529  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q16665
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Peptide
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:500

    ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • ARNT interacting protein antibody
    ARNT-interacting protein antibody
    Basic helix loop helix PAS protein MOP1 antibody
    Basic-helix-loop-helix-PAS protein MOP1 antibody
    bHLHe78 antibody
    Class E basic helix-loop-helix prote
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB,ICC,FC
  • Background：  
  • Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.



 
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