Product Datasheet  
Fusion glycoprotein F0 Antibody  
Catalog Number: 48527  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:W8CLH7
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Peptide
  • reactivity：  
  • Avian avulavirus 1
  • appl_detail：  
  • WB: 1:500-1,000



  • other_names：  
  • F antibody
    Fusion glycoprotein F0 antibody
    Protein F antibody
    RSV Fusion (F) Glycoprotein antibody
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB
  • Background：  
  • During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.



 
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