Product Datasheet  
Mitofusin 2 Antibody  
Catalog Number: 48524  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O95140
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein
  • reactivity：  
  • Hu, Rt
  • appl_detail：  
  • WB: 1:500-1:1,000

    ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • CMT2A antibody
    CMT2A2 antibody
    CPRP 1 antibody
    CPRP1 antibody
    EC 3.6.5.- antibody
    Fzo antibody
    HSG antibody
    hyperplasia suppressor gene antibody
    Hypertension related protein 1 antibody
  • Purification：  
  • Protein affinity purified
  • Specificity：  
  • Applications：  
  • WB,ICC,FC
  • Background：  
  • Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.



 
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