Product Datasheet  
SIRT1 Antibody  
Catalog Number: 48501  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q96EB6
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:1,000-1:2,000
    IHC: 1:200


    FC: 1:100-1:200
  • other_names：  
  • 75SirT1 antibody
    hSIR2 antibody
    hSIRT1 antibody
    HST2, S. cerevisiae, homolog of antibody
    NAD dependent deacetylase sirtuin 1 antibody
    NAD dependent protein deacetylase sirtuin 1 antibody
    OTTHUMP00000198111 antibody
    OTTHU
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, IHC, FC
  • Background：  
  • SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARγ, and the PPARγ coactivator-1α (PGC-1α) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol.



 
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