Product Datasheet  
N-Cadherin Antibody  
Catalog Number: 48495  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P19022
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide (KLH-coupled) within human N-cadherin 360-420 aa.
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:500
    IHC: 1:200
    ICC: 1:200

    FC: 1:50
  • other_names：  
  • CADH2_HUMAN antibody
    Cadherin 2 antibody
    Cadherin 2 N cadherin neuronal antibody
    Cadherin 2 type 1 antibody
    Cadherin 2 type 1 N cadherin neuronal antibody
    Cadherin 2, type 1, N-cadherin (neuronal) antibody
    Cadheri
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins.



 
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